Article
Genetic association between alpha-synuclein and idiopathic Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008
Kay Denise M, Factor Stewart A, Samii Ali, Higgins Donald S, Griffith Alida, Roberts John W, Leis Berta C, Nutt John G, Montimurro Jennifer S, Keefe Robert G, Atkins April J, Yearout Dora, Zabetian Cyrus P, Payami Haydeh
Abstract excerpt
Point mutations and copy number variations in SNCA, the gene encoding alpha-synuclein, cause familial Parkinson's disease (PD). A dinucleotide polymorphism (REP1) in the SNCA promoter may be a risk factor for common forms of PD. We studied 1,802 PD patients and 2,129 controls from the NeuroGenetics Research Consortium, using uniform, standardized protocols for diagnosis, subject recruitment, data collection,...
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