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Article

α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease.

PloS one - 1 Jan 2012

Ritz Beate, Rhodes Shannon L, Bordelon Yvette, Bronstein Jeff

Abstract excerpt

Currently, there are no reported genetic predictors of motor symptom progression in Parkinson's disease (PD). In familial PD, disease severity is associated with higher α-synuclein (SNCA) expression levels, and in postmortem studies expression varies with SNCA genetic variants. Furthermore, SNCA is a well-known risk factor for PD occurrence. We recruited Parkinson's patients from the communities of three central...

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Identifiers

PMID: 22615757
DOI: 10.1371/journal.pone.0036199
PMCID: PMC3352914

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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