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Article

Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.

Journal of neurology - 1 Mar 2012

Hu Yacen, Tang Beisha, Guo Jifeng, Wu Xintian, Sun Qiying, Shi Changhe, Hu Liang, Wang Chunyu, Wang Lei, Tan Liming, Shen Lu, Yan Xinxiang, Zhang Hainan

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disorder. The presence of Lewy bodies is a major pathological change of PD. α-synuclein is the main component of Lewy bodies and is encoded by the SNCA gene. Mutations in the SNCA gene mainly result in rare familial forms of PD, while genetic variability in the SNCA gene modulates susceptibility to sporadic PD. Recent studies have suggested that...

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Identifiers

PMID: 21853288
DOI: 10.1007/s00415-011-6209-4

Genes

SNCA

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