Article
Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.
Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2006
Hadjigeorgiou Georgios M, Xiromerisiou Georgia, Gourbali Vanessa, Aggelakis Kostantinos, Scarmeas Nikolaos, Papadimitriou Alexandros, Singleton Andrew
Abstract excerpt
The alpha-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was...
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