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Article

Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?

Parkinsonism & related disorders - 1 Jun 2014

Markopoulou Katerina, Biernacka Joanna M, Armasu Sebastian M, Anderson Kari J, Ahlskog J Eric, Chase Bruce A, Chung Sun Ju, Cunningham Julie M, Farrer Matthew, Frigerio Roberta, Maraganore Demetrius M

Abstract excerpt

α-Synuclein gene (SNCA) multiplications cause familial parkinsonism and allele-length polymorphisms within the SNCA dinucleotide repeat REP1 increase the risk for developing Parkinson's disease (PD). Since SNCA multiplications increase SNCA expression, and REP1 genotypes that increase the risk of developing PD show increased SNCA expression in cell-culture systems, animal models, and human blood and brain, PD...

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Identifiers

PMID: 24656894
DOI: 10.1016/j.parkreldis.2014.02.021
PMCID: PMC4723426

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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