Article

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

2020-04-13

Abstract excerpt

<h4>Summary</h4> NF-κB and MYC are found co-deregulated in human B and plasma-cell cancers. In physiology, NF-κB is necessary for terminal B-to-plasma cell differentiation, whereas MYC repression is required. It is thus unclear if NF-κB/MYC co-deregulation is developmentally compatible in carcinogenesis and/or impacts cancer cell differentiation state, possibly uncovering unique sensitivities. Using a mouse syste...

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Literature Corpus work: 075106a0-3495-5145-b455-7d2d1736dbca
DOI: 10.1101/2020.04.12.038414

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