Article

Sympathoadrenal Lineage Plasticity Drives Intratumoral Heterogeneity in Paraganglioma, Neuroblastoma and Composite Tumors Following KIF1Bβ-NF1 Loss

2026-04-10

Abstract excerpt

Neuroblastoma (NB) and paraganglioma (PPGL) arise from the sympathoadrenal lineage and often occur in the adrenal medulla, however their developmental relationship and the mechanisms underlying their heterogeneity remain unknown. Using a genetically engineered mouse model, we show that loss of KIF1Bβ , a candidate 1p36 tumor suppressor, cooperates with Nf1 loss in tumorigenesis and cell-state reprogramming withi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2400f0ab-6cf9-5198-b8a3-97f34f036e30
DOI: 10.64898/2026.04.07.715303

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sympathoadrenal Lineage Plasticity Drives Intratumoral Heterogeneity in Paraganglioma, Neuroblastoma and Composite Tumors Following KIF1Bβ-NF1 LossDOI 10.64898/2026.04.07.715303Read

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.Semantic proximity Read

Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma.Semantic proximity Read

Dominant Malignant Clones Leverage Lineage Restricted Epigenomic Programs to Drive Ependymoma DevelopmentSemantic proximity Read

Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectorySemantic proximity Read

Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectorySemantic proximity Read

Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticitySemantic proximity Read

Single-cell RNA-sequencing of peripheral neuroblastic tumors reveals an aggressive transitional cell state at the junction of an adrenergic-mesenchymal transdifferentiation trajectorySemantic proximity Read

Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell StateSemantic proximity Read

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneitySemantic proximity Read

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumorsSemantic proximity Read

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumorsSemantic proximity Read