Article
NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors.
BMC cancer - 29 May 2012
McCarthy Brian A, Yang Liqun, Ding Jane, Ren Mingqiang, King William, ElSalanty Mohammed, Zakhary Ibrahim, Sharawy Mohamed, Cui Hongjuan, Ding Han-Fei
Abstract excerpt
BACKGROUND: Abnormal NF-κB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-κB2 signaling in the development of plasma cell tumors has not been established. Also unclear is the molecular mechanism that drives the tumorigenic process. We investigated these questions by using a transgenic mouse model with lymphocyte-targeted...
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