Article

Preclinical models of human multiple myeloma subgroups

2021-08-28

Abstract excerpt

Multiple myeloma (MM), a tumor of germinal center (GC)-experienced plasma cells, comprises distinct genetic subgroups, such as the t(11;14)/CCND1 and the t(4;14)/MMSET subtype. We have generated subgroup-specific MM models by the GC B cell-specific co-activation of Ccnd1 or MMSET with a constitutively active Ikk2 mutant, mimicking the secondary NFκB activation frequently seen in human MM. Ccnd1/Ikk2ca and MMSET/Ik...

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Literature Corpus work: a9dac96e-ef84-5474-b3b6-72ac0ca6f38c
DOI: 10.1101/2021.08.28.458010

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