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ZNF423 depletion induces the integrated stress response and represents a potential vulnerability in NF1-associated MPNST

2026-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited systemic therapies and represent the leading cause of mortality for individuals with neurofibromatosis type 1 (NF1). Malignant progression can reactivate developmental precursor programs that are largely absent from normal nerve and benign tumors, creating tumor-selective vulnerabilities. Zinc finger protein 42...

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Literature Corpus work
c8f1d86e-24db-5193-94f1-5f63e5776331
DOI
10.64898/2026.03.03.709360
Open publication

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