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Article

NFKB1 as a key player in Tumor biology: from mechanisms to therapeutic implications.

Cell biology and toxicology - 11 Jan 2025

Song Zixuan, Feng Zheng, Wang Xiaoxue, Li Jingying, Zhang Dandan

Abstract excerpt

NFKB1, a core transcription factor critical in various biological process (BP), is increasingly studied for its role in tumors. This research combines literature reviews, meta-analyses, and bioinformatics to systematically explore NFKB1's involvement in tumor initiation and progression. A unique focus is placed on the NFKB1-94 ATTG promoter polymorphism, highlighting its association with cancer risk across...

Topics

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Computational Biology
Gene Expression Regulation, Neoplastic
NFKB1 gene
Genetic Predisposition to Disease
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NF-κB Signaling Pathways

NF-kappa B p50 Subunit

Promoter Regions, Genetic

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Identifiers

PMID: 39797972
DOI: 10.1007/s10565-024-09974-2
PMCID: PMC11724797

Genes

NFKB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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