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Article

Myc suppression of Nfkb2 accelerates lymphomagenesis

2 Jul 2010

Abstract excerpt

BACKGROUND: Deregulated c-Myc expression is a hallmark of several human cancers where it promotes proliferation and an aggressive tumour phenotype. Myc overexpression is associated with reduced activity of Rel/NF-kappaB, transcription factors that control the immune response, cell survival, and transformation, and that are frequently altered in cancer. The Rel/NF-kappaB family member NFKB2 is altered by...

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PMID: 20598117
DOI: 10.1186/1471-2407-10-348

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