Article

A bacterial pan-genome makes gene essentiality strain-dependent and evolvable

2022-02-09

Abstract excerpt

Many bacterial species are represented by a pan-genome, whose genetic repertoire far outstrips that of any single bacterial genome. Here we investigate how a bacterial pan-genome might influence gene essentiality, and whether essential genes that are initially critical for the survival of an organism can evolve to become non-essential. By using Tn-Seq, whole-genome sequencing, and RNA-Seq on a set of 36 clinical...

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Literature Corpus work: 075057be-67b1-56ae-95c4-0d8003352b31
DOI: 10.1101/2022.02.08.479609

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