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Essential Genes in the Core Genome of the Human Pathogen Streptococcus pyogenes

21 May 2015

Abstract excerpt

Streptococcus pyogenes (Group A Streptococcus, GAS) remains a major public health burden worldwide, infecting over 750 million people leading to over 500,000 deaths annually. GAS pathogenesis is complex, involving genetically distinct GAS strains and multiple infection sites. To overcome fastidious genetic manipulations and accelerate pathogenesis investigations in GAS, we developed a mariner-based system (Krmit)...

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PMID: 25996237
DOI: 10.1038/srep09838

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