Article
Comparative analysis of gene importance in Escherichia coli across growth conditions.
mSystems - 19 May 2026
Champie Antoine, Jeanneau Simon, De Grandmaison Amélie, Martin Silva Mathias, Coté Jean-Philippe, Jacques Pierre-Étienne, Rodrigue Sébastien
Abstract excerpt
As the ability to synthesize complete genomes becomes increasingly possible, the question of what should compose those sequences is becoming more prevalent. However, identifying genes essential for the survival of an organism is challenging, as gene essentiality is a nuanced concept that heavily depends on context. In this study, we identified growth medium-specific fitness-impacting genes by performing...
Topics
- Escherichia coli
- Genes, Essential
- DNA Transposable Elements
- Genes, Bacterial
- Culture Media
- Mutagenesis, Insertional
- Mutation
- Genome, Bacterial
- Escherichia coli Proteins