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Article

Experimental evolution of gene essentiality in bacteria.

mBio - 10 Dec 2025

Bao Liang, Zhu Zan, Ismail Ahmed, Zhu Bin, Anandan Vysakh, Whiteley Marvin, Kitten Todd, Xu Ping

Abstract excerpt

Essential gene products carry out fundamental cellular activities in interaction with other components. However, the lack of essential gene mutants and appropriate methodologies to link essential gene functions with their partners poses significant challenges. We report here the generation in Streptococcus sanguinis strain SK36 of deletion mutants in 32 genes previously identified as essential, with 23 mutants...

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Identifiers

PMID: 41170999
DOI: 10.1128/mbio.03005-25
PMCID: PMC12691585

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