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Article

Combining Shigella Tn-seq data with gold-standard E. coli gene deletion data suggests rare transitions between essential and non-essential gene functionality.

BMC microbiology - 6 Sept 2016

Freed Nikki E, Bumann Dirk, Silander Olin K

Abstract excerpt

BACKGROUND: Gene essentiality - whether or not a gene is necessary for cell growth - is a fundamental component of gene function. It is not well established how quickly gene essentiality can change, as few studies have compared empirical measures of essentiality between closely related organisms. RESULTS: Here we present the results of a Tn-seq experiment designed to detect essential protein coding genes in the...

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Identifiers

PMID: 27599549
DOI: 10.1186/s12866-016-0818-0
PMCID: PMC5011829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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