Article

Fusion-derived phospho-neoepitopes define a prioritized candidate neoantigen repertoire in MASLD-HCC

2026-08-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The rising burden of metabolic dysfunction-associated steatotic liver disease (MASLD)-associated hepatocellular carcinoma (HCC) underscores the need for innovative therapeutic strategies. <h4>Methods</h4> We integrated RNA-seq fusion detection, immunopeptidomics, and proteogenomics to systematically prioritize tumor-specific neoantigen candidates arising from gene fusions i...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 06b1bb1e-6bd0-598f-a154-3f95e650eeeb
DOI: 10.64898/2026.08.26.747243

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Fusion-derived phospho-neoepitopes define a prioritized candidate neoantigen repertoire in MASLD-HCCDOI 10.64898/2026.08.26.747243Read

Decoding Neoantigen-encoding Tumor-Specific Transcripts Unveils a Shared Target Reservoir for Immunotherapy in Hepatocellular CarcinomaSemantic proximity Read

Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identificationSemantic proximity Read

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltrationSemantic proximity Read

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigensSemantic proximity Read

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC.Semantic proximity Read

Pan-cancer proteogenomics expands the landscape of therapeutic targetsSemantic proximity Read

Multiomics prediction and immunogenic validation of personalized neoantigens in cholangiocarcinoma patients.Semantic proximity Read

Profiling of hepatocellular carcinoma neoantigens reveals immune microenvironment and clonal evolution related patternsSemantic proximity Read

Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinomaSemantic proximity Read

Tumour-wide RNA splicing aberrations generate actionable public neoantigensSemantic proximity Read

The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinomaSemantic proximity Read

Repurposing public sarcoma multi-omics for neoantigen discoverySemantic proximity Read