Article

Decoding Neoantigen-encoding Tumor-Specific Transcripts Unveils a Shared Target Reservoir for Immunotherapy in Hepatocellular Carcinoma

2025-12-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Primary liver cancer, predominantly hepatocellular carcinoma (HCC), has limited therapeutic options. While mutation-derived neoantigen vaccine holds promise, its success is hindered by low antigen availability. This study explores transcriptome-derived neoantigens (neoantigen-encoding tumor-specific transcripts, neoTSTs) in HCC, characterizing their features, genera...

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Literature Corpus work: d27ebb92-b495-5847-b13d-8317ee6a9dfd
DOI: 10.64898/2025.12.07.692877

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