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Article

Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

30 Apr 2019

Abstract excerpt

BACKGROUND: Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). Employing a unique multi-omics approach comprising a neoepitope identification pipeline, we assessed exome-derived mutations naturally presented as HLA class I ligands in HCCs. METHODS: In-depth multi-omics analyses included whole...

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PMID: 31039795
DOI: 10.1186/s13073-019-0636-8

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