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Article

Multiomics prediction and immunogenic validation of personalized neoantigens in cholangiocarcinoma patients.

Journal of translational medicine - 17 Jun 2026

Zhang Baoluhe, Jin Bao, Wan Xueshuai, Liu Xiao, Wu Xiang'an, Xing Jiali, Wang Yuxin, Xu Haifeng, Xu Yiyao, Guan Mei, Mao Yilei, Bai Yating, Zhu Junqi, Chen Qian, Du Shunda

Abstract excerpt

BACKGROUND: Cholangiocarcinoma (CCA) is an aggressive biliary tract cancer with limited treatment options, underscoring the need for breakthrough precision therapies. Neoantigen-based therapy is a promising novel strategy for cancer treatment. This study investigates the potential of neoantigen peptides in CCA, emphasizing their role in personalized immunotherapy and providing insights for vaccine design....

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Source

Open in PubMed Open full text

Identifiers

PMID: 42310758
DOI: 10.1186/s12967-026-08471-w
PMCID: PMC13523427

Genes

ITPR2
TP53
UBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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