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Pan-cancer proteogenomics expands the landscape of therapeutic targets

24 Jun 2024

Abstract excerpt

Fewer than 200 proteins are targeted by cancer drugs approved by the Food and Drug Administration (FDA). We integrate Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomics data from 1,043 patients across 10 cancer types with additional public datasets to identify potential therapeutic targets. Pan-cancer analysis of 2,863 druggable proteins reveals a wide abundance range and identifies biological...

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PMID: 38917788
DOI: 10.1016/j.cell.2024.05.039

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