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Article

Profiling of hepatocellular carcinoma neoantigens reveals immune microenvironment and clonal evolution related patterns

1 Jan 2021

Abstract excerpt

OBJECTIVE: Neoantigens derived from tumor-specific genomic alterations have demonstrated great potential for immunotherapeutic interventions in cancers. However, the comprehensive profile of hepatocellular carcinoma (HCC) neoantigens and their complex interplay with immune microenvironment and tumor evolution have not been fully addressed. METHODS: Here we integrated whole exome sequencing data, transcriptome...

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PMID: 34321833
DOI: 10.21147/j.issn.1000-9604.2021.03.08

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