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Article

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC.

Cell genomics - 14 Jan 2026

Xiang Haitao, Guan Xiangyu, Wei Yaohua, Luo Shuzhen, Zhang Haibo, Bu Fanyu, Yan Yixin, Fu Yunyun, Li Yijian, Xu Qumiao, Lin Penghui, Liu Dongbing, Zhou Xinlan, Gao Feng, Chen Tai, Nie Guangjun, Wu Kui, Gu Ying, Liu Longqi, Ye Ziqing, Wu Xiaojian, Zhao Ruifang, Liu Siqi, Dong Xuan

Abstract excerpt

Tumor-specific antigens (TSAs) are crucial for activating T cells against cancer, but traditional discovery methods focusing on exonic mutations overlook non-canonical TSAs from non-coding regions. We employed an integrative proteogenomic strategy combining whole-genome and RNA sequencing with immunoprecipitation mass spectrometry to comprehensively explore TSA generation in colorectal cancer patients. Analysis...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41237784
DOI: 10.1016/j.xgen.2025.101062
PMCID: PMC12926194

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