Article

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

2021-07-11

Abstract excerpt

The signalling pathways that maintain primed human pluripotent stem cells (hPSCs) have been well characterised, revealing a critical role for TGFβ/Activin/Nodal signalling. In contrast, the signalling requirements of naïve human pluripotency have not been fully established. Here, we demonstrate that TGFβ signalling is required to maintain naïve hPSCs. The downstream effector proteins – SMAD2/3 – bind common sites...

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Literature Corpus work: 17f3cb66-1044-5611-b3cb-37e56d278103
DOI: 10.1101/2021.07.10.451887

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