Article

Modulating CRISPR gene drive activity through nucleocytoplasmic localization of Cas9 in <i>S. cerevisiae</i>

2018-09-04

Abstract excerpt

<h4>ABSTRACT</h4> The bacterial CRISPR/Cas genome editing system has provided a major breakthrough in molecular biology. One use of this technology is within a nuclease-based gene drive. This type of system can install a genetic element within a population at unnatural rates. Combatting of vector-borne diseases carried by metazoans could benefit from a delivery system that bypasses traditional Mendelian laws of s...

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Literature Corpus work: 064b1533-275b-50e7-8e0e-92c47ed05b2a
DOI: 10.1101/408369

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