Transcriptional Regulation Technology for Gene Perturbation in Fission Yeast.

Abstract excerpt

Isolation and introduction of genetic mutations is the primary approach to characterize gene functions in model yeasts. Although this approach has proven very powerful, it is not applicable to all genes in these organisms. For example, introducing defective mutations into essential genes causes lethality upon loss of function. To circumvent this difficulty, conditional and partial repression of target...

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• Share to CRISPR-Cas Systems
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• Share to Gene Expression Regulation, Fungal
• Share to Gene Knockdown Techniques
• Share to Genome-Wide Association Study
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• Share to Schizosaccharomyces
• Share to Transcription, Genetic