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Human Cancer Cells Commonly Acquire DNA Damage during Mitotic Arrest

15 Dec 2007

Abstract excerpt

The mitotic checkpoint is a mechanism that arrests the progression to anaphase until all chromosomes have achieved proper attachment to mitotic spindles. In cancer cells, satisfaction of this checkpoint is frequently delayed or prevented by various defects, some of which have been causally implicated in tumorigenesis. At the same time, deliberate induction of mitotic arrest has proved clinically useful, as...

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PMID: 18089775
DOI: 10.1158/0008-5472.can-07-5162

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