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Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING

14 May 2024

Abstract excerpt

The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a pivotal role in innate immune responses to viral infection and inhibition of autoimmunity. Recent studies have suggested that micronuclei formed by genotoxic stress can activate innate immune signaling via the cGAS-STING pathway. Here, we investigated cGAS localization, activation, and downstream...

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PMID: 38749421
DOI: 10.1016/j.molcel.2024.04.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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