Article

DNA damage checkpoints balance a tradeoff between diploid- and polyploid-derived arrest failures

2025-02-16

Abstract excerpt

<h4>SUMMARY</h4> The DNA damage checkpoint system ensures genomic integrity by preventing the division of damaged cells. This system operates primarily through the G1/S and G2/M checkpoints, which are susceptible to failure; how these checkpoints coordinate quantitatively to ensure optimal cellular outcomes remains unclear. In this study, we exposed non-cancerous human cells to exogenous DNA damage and used singl...

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Literature Corpus work: d0603796-fc3f-5493-b2b4-05ae2a3b35a2
DOI: 10.1101/2025.02.14.638318

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