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Article

Profiling DNA damage response following mitotic perturbations.

Nature communications - 15 Dec 2016

S Pedersen Ronni, Karemore Gopal, Gudjonsson Thorkell, Rask Maj-Britt, Neumann Beate, Hériché Jean-Karim, Pepperkok Rainer, Ellenberg Jan, Gerlich Daniel W, Lukas Jiri, Lukas Claudia

Abstract excerpt

Genome integrity relies on precise coordination between DNA replication and chromosome segregation. Whereas replication stress attracted much attention, the consequences of mitotic perturbations for genome integrity are less understood. Here, we knockdown 47 validated mitotic regulators to show that a broad spectrum of mitotic errors correlates with increased DNA breakage in daughter cells. Unexpectedly, we find...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27976684
DOI: 10.1038/ncomms13887
PMCID: PMC5172227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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