Article

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model

2024-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Lysosomal dysfunction is causally linked to neurodegeneration in many lysosomal storage disorders (LSDs) and is associated with various age-related neurodegenerative diseases 1,2 , but there is limited understanding of the mechanisms by which altered lysosomal function leads to changes in gene expression that drive pathogenic cellular phenotypes. To investigate this question, we performed syste...

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Literature Corpus work: 06087fb4-297d-5e1d-9c37-d66fe9120a12
DOI: 10.1101/2024.11.12.623296

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