Article

Single-nucleus profiling identifies accelerated oligodendrocyte precursor cell senescence in a mouse model of Down Syndrome

2023-04-17

Abstract excerpt

Down Syndrome (DS), the most common genetic cause of intellectual disability, is associated with lifelong cognitive disability. However, the mechanisms by which triplication of human chromosome 21 genes drive neuroinflammation and cognitive dysfunction are poorly understood. Here, using the Ts65Dn mouse model of DS, we performed an integrated single-nucleus RNA and ATAC-seq analysis of the cortex. We identify cell...

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Literature Corpus work: b348d1e0-b645-5be4-bba1-bf089144c308
DOI: 10.1101/2023.04.17.537139

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