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Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health

23 Apr 2025

Abstract excerpt

BACKGROUND: Genetic variation in Transmembrane protein 106B (TMEM106B) is known to influence the risk and presentation in several neurodegenerative diseases and modifies healthy aging. While evidence from human studies suggests that the risk allele is associated with higher levels of TMEM106B, the contribution of elevated levels of TMEM106B to neurodegeneration and aging has not been assessed and it remains...

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PMID: 40269985
DOI: 10.1186/s13024-025-00831-2

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