Loss of tumour suppressor p53 rewires enhancer landscape and governs oncogenic progression

Abstract excerpt

Mutations in tumour suppressor p53 confer enhanced metastasis and chemoresistance in colorectal cancer (CRC). Though the genetic events regulating CRC with p53 loss/mutation have been documented, the epigenetic events accompanying the loss of p53 have not been well understood. Epigenome based classification of CRC tumours has identified the active enhancer mark as a distinct marker for progression, however the rol...

Topics

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• Datasets as Topic
• Enhancer Elements, Genetic
• Epigenomics
• Genetic Loci
• Mice, Nude
• Tissue Array Analysis
• Transcription Factor AP-1
• Xenograft Model Antitumor Assays

Identifiers and source

Literature Corpus work

05f1b118-b9f0-5ab5-bbb7-c1c862d9925a

DOI

10.1101/2025.07.28.667341