Article
Epigenomic enhancer profiling defines a signature of colon cancer.
Science (New York, N.Y.) - 11 May 2012
Akhtar-Zaidi Batool, Cowper-Sal-lari Richard, Corradin Olivia, Saiakhova Alina, Bartels Cynthia F, Balasubramanian Dheepa, Myeroff Lois, Lutterbaugh James, Jarrar Awad, Kalady Matthew F, Willis Joseph, Moore Jason H, Tesar Paul J, Laframboise Thomas, Markowitz Sanford, Lupien Mathieu, Scacheri Peter C
Abstract excerpt
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, even though distal regulatory elements play a central role in controlling transcription patterns. We used the histone mark H3K4me1 to analyze gain and loss of enhancer activity genome-wide in primary colon cancer lines relative to normal colon crypts. We identified thousands of variant enhancer...
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