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Epigenetic Gatekeeping of Wnt-Responsive Enhancers Restricts Intestinal Stem Cell Transformation

2026-02-03

Abstract excerpt

<h4>ABSTRACT</h4> Widespread cell plasticity recognized in fetal intestinal epithelium is preserved in limited fashion in Wnt-responsive adult stem cells and contributes to tumour initiation, progression, and relapse. It is unclear which epigenetic features maintain stem-cell properties, restrict adult expression of fetal genes, and are attenuated in tumours, allowing non-stem cells to replenish targeted tumour s...

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Literature Corpus work
9fa9f59e-5484-5e93-8cb8-f38f9157466f
DOI
10.64898/2026.01.31.702974
Open publication

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Epigenetic Gatekeeping of Wnt-Responsive Enhancers Restricts Intestinal Stem Cell TransformationDOI 10.64898/2026.01.31.702974
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