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Article

Crystal Structure of the Human BRD2 Bromodomain

6 Dec 2006

Abstract excerpt

The BET (bromodomains and extra terminal domain) family proteins recognize acetylated chromatin through their bromodomain and act as transcriptional activators. One of the BET proteins, BRD2, associates with the transcription factor E2F, the mediator components CDK8 and TRAP220, and RNA polymerase II, as well as with acetylated chromatin during mitosis. BRD2 contains two bromodomains (BD1 and BD2), which are...

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PMID: 17148447
DOI: 10.1074/jbc.m605971200

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Crystal Structure of the Human BRD2 BromodomainPMID 17148447Read ↗

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