Article
Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011
Lamonica Janine M, Deng Wulan, Kadauke Stephan, Campbell Amy E, Gamsjaeger Roland, Wang Hongxin, Cheng Yong, Billin Andrew N, Hardison Ross C, Mackay Joel P, Blobel Gerd A
Abstract excerpt
Acetylation of histones triggers association with bromodomain-containing proteins that regulate diverse chromatin-related processes. Although acetylation of transcription factors has been appreciated for some time, the mechanistic consequences are less well understood. The hematopoietic transcription factor GATA1 is acetylated at conserved lysines that are required for its stable association with chromatin. We...
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