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Article

Effect Sizes of Somatic Mutations in Cancer

24 Aug 2018

Abstract excerpt

A major goal of cancer biology is determination of the relative importance of the genetic alterations that confer selective advantage to cancer cells. Tumor sequence surveys have frequently ranked the importance of substitutions to cancer growth by P value or a false-discovery conversion thereof. However, P values are thresholds for belief, not metrics of effect. Their frequent misuse as metrics of effect has...

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PMID: 30365005
DOI: 10.1093/jnci/djy168

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