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Article

Tobacco Smoking-Related Mutational Signatures in Classifying Smoking-Associated and Nonsmoking-Associated NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2023

Ernst Sophie M, Mankor Joanne M, van Riet Job, von der Thüsen Jan H, Dubbink Hendrikus J, Aerts Joachim G J V, de Langen Adrianus J, Smit Egbert F, Dingemans Anne-Marie C, Monkhorst Kim

Abstract excerpt

INTRODUCTION: Patient-reported smoking history is frequently used as a stratification factor in NSCLC-directed clinical research. Nevertheless, this classification does not fully reflect the mutational processes in a tumor. Next-generation sequencing can identify mutational signatures associated with tobacco smoking, such as single-base signature 4 and indel-based signature 3. This provides an opportunity to...

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Identifiers

PMID: 36528243
DOI: 10.1016/j.jtho.2022.11.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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