Article
Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.
International journal of oral science - 24 Apr 2026
Deneuve Sophie, Fervers Béatrice, Bruno Julia S, Bach Emma, Senkin Sergey, Goldman-Lévy Gabrielle, Carreira Christine, Laklouk Israa, Hu Rong, Bouaoun Liacine, Pérol Olivia, Chavanel Bérénice, Lu Lingeng, Lozar Taja, Gheit Tarik, Lambert Paul F, Coste Isabelle, Renno Toufic, Zavadil Jiri, Virard François
Abstract excerpt
Tobacco use, alcohol consumption, and infection with human papilloma virus (HPV) are well-established risk factors for head and neck squamous cell carcinomas (HNSCC). However, the incidence of oral cancer, particularly in the mobile tongue, has been rising in non-smoker/non-drinker and HPV-negative patients, suggesting the emergence of a new clinical entity. To understand in molecular terms this subtype of oral...
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