Article

Identification of a tobacco-smoking induced mutation signature with biological and clinical significance in bladder cancer

2022-02-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Tobacco-smoking is a known risk factor for bladder cancer (BCa). However, a typical tobacco-smoking induced mutation signature, COSMIC SBS4, established in lung and head-and-neck cancer, has not yet been virtually found in BCa. <bold>Methods:</bold> De novo mutation signature extraction was performed. Association of SBS4-like signature with tobacco-smoking and c...

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Literature Corpus work: 41fbc3d8-50b9-57aa-965a-8178719a7e87
DOI: 10.21203/rs.3.rs-1324265/v1

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