Article
Tobacco smoking and somatic mutations in human bronchial epithelium.
Nature - 1 Feb 2020
Yoshida Kenichi, Gowers Kate H C, Lee-Six Henry, Chandrasekharan Deepak P, Coorens Tim, Maughan Elizabeth F, Beal Kathryn, Menzies Andrew, Millar Fraser R, Anderson Elizabeth, Clarke Sarah E, Pennycuick Adam, Thakrar Ricky M, Butler Colin R, Kakiuchi Nobuyuki, Hirano Tomonori, Hynds Robert E, Stratton Michael R, Martincorena Iñigo, Janes Sam M, Campbell Peter J
Abstract excerpt
Tobacco smoking causes lung cancer1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6-10, but equivalent data for normal bronchial cells are lacking. Here we sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16...
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