Article
The repertoire of mutational signatures in human cancer.
Nature - 1 Feb 2020
Alexandrov Ludmil B, Kim Jaegil, Haradhvala Nicholas J, Huang Mi Ni, Tian Ng Alvin Wei, Wu Yang, Boot Arnoud, Covington Kyle R, Gordenin Dmitry A, Bergstrom Erik N, Islam S M Ashiqul, Lopez-Bigas Nuria, Klimczak Leszek J, McPherson John R, Morganella Sandro, Sabarinathan Radhakrishnan, Wheeler David A, Mustonen Ville, Getz Gad, Rozen Steven G, Stratton Michael R
Abstract excerpt
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we characterized mutational signatures using 84,729,690 somatic mutations from 4,645 whole-genome and...
Topics
- Age Factors
- Base Sequence
- Exome
- Genome, Human
- Humans
- Mutation
- Neoplasms
- Sequence Analysis, DNA