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Article

Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel.

Proteins - 1 Dec 2016

Li Junwei, Xiao Shaoying, Xie Xiaoxiao, Zhou Hui, Pang Chunli, Li Shanshan, Zhang Hailin, Logothetis Diomedes E, Zhan Yong, An Hailong

Abstract excerpt

Kir2.1 (also known as IRK1) plays key roles in regulation of resting membrane potential and cell excitability. To achieve its physiological roles, Kir2.1 performs a series of conformational transition, named as gating. However, the structural basis of gating is still obscure. Here, we combined site-directed mutation, two-electrode voltage clamp with molecular dynamics simulations and determined that H221...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27699887
DOI: 10.1002/prot.25176
PMCID: PMC5317092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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