Article
Identification of a proton sensor that regulates conductance and open time of single hERG channels.
Scientific reports - 27 Dec 2019
Wilson Stacey L, Dempsey Christopher E, Hancox Jules C, Marrion Neil V
Abstract excerpt
The hERG potassium channel influences ventricular action potential duration. Extracellular acidosis occurs in pathological states including cardiac ischaemia. It reduces the amplitude of hERG current and speeds up deactivation, which can alter cardiac excitability. This study aimed to identify the site of action by which extracellular protons regulate the amplitude of macroscopic hERG current. Recordings of...
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