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An in vitro stem cell model of human epiblast and yolk sac interaction

17 Aug 2021

Abstract excerpt

Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models. Here, we have established conditions to differentiate human pluripotent stem cells (hPSCs) into yolk sac-like cells (YSLCs) that resemble the post-implantation...

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PMID: 34403333
DOI: 10.7554/elife.63930

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