Article

A Single-Cell Transcriptomic Atlas of Symmetry Breaking Across Eutherian Mammals

2026-03-02

Abstract excerpt

The mammalian body plan is established during symmetry breaking and gastrulation. In ungulates and primates, these events occur within a flat embryonic disc and coincide with the developmental window most susceptible to pregnancy loss. Here, we generated a single-cell RNA sequencing atlas of in vivo sheep embryos that defines the timing and molecular programs underlying lineage segregation, as well as the inter-l...

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Literature Corpus work: d15b7501-2be7-573d-9fa9-b4ba0db83692
DOI: 10.64898/2026.02.27.708463

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