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Article

Monogenic and polygenic concepts in chronic kidney disease (CKD).

Journal of nephrology - 1 Jan 2024

Jefferis Julia, Hudson Rebecca, Lacaze Paul, Bakshi Andrew, Hawley Carmel, Patel Chirag, Mallett Andrew

Abstract excerpt

Kidney function is strongly influenced by genetic factors with both monogenic and polygenic factors contributing to kidney function. Monogenic disorders with primarily autosomal dominant inheritance patterns account for 10% of adult and 50% of paediatric kidney diseases. However, kidney function is also a complex trait with polygenic architecture, where genetic factors interact with environment and lifestyle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Renal Insufficiency, Chronic

Source

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Identifiers

PMID: 37989975
DOI: 10.1007/s40620-023-01804-8
PMCID: PMC10920206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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